Objective: To study the effects of ultraviolet-treatment of titanium implant on the integration of implant with bone in type 2 diabetic rats. Methods: Ultraviolet-treated titanium implants ( experimental grtoup, n = 32) and un-treated titanium implants ( control group, n = 32) were inserted into the distal tibia of type 2 diabetic rats respectively. 4 and 8 weeks after implantation, the rats were sacrificed for histomorphometry analysis and biomechanical test for the evaluation of bone-implant osseointegration. Results: The max bio-mechanical pull-out force(N) was (88. 1 ±13.3) in control group and (171.6 ±24.4) in test group(P<0.05) 4 weeks after implantation, (107.2±15.0) and (221.7 ±14. 6) (P <0. 05) 8 weeks after implantation, respectively. Ponceau staining showed that the bone-implant-contact(% ) was (41.7 ±2.4) in control group and (61. 1 ±2.5) in test group(P <0.05) 4 weeks after implantation, (48.8 ±2.5) and (71.7±4.2)(P<0.05) 8 weeks after implantation, respectively. Conclusion: Ultraviolet-photofunctionalization may improve bone-implant osseointegration in type 2 diabetic rats.%目的:评价紫外光机能化种植体表面对2型糖尿病大鼠种植体骨结合的影响.方法:将紫外光未处理和紫外光处理种植体植入2型糖尿病大鼠胫骨近骺端,每组16只大鼠32枚种植体.术后4、8周处死取材,通过生物力学测试和硬组织切片分析2组大鼠种植体骨结合的差异.结果:术后4周时生物力学最大拔出力(N),对照组(88.1±13.3),实验组(171.6±24.4) (P ＜0.05)；8周时对照组(107.2±15.0),实验组(221.7±14.6) (P ＜0.05).组织学分析显示,4周时对照组骨-种植体接触率(％)(41.7±2.4),实验组(61.1±2.5)(P＜0.05)；8周时对照组骨-种植体接触率(％)(48.8±2.5),实验组(71.7±4.2)(P＜0.05).结论:光机能化种植体表面可提高2型糖尿病大鼠种植体骨结合.
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