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自体牙移植到人工牙槽窝的动物实验

     

摘要

Objective: To observe morphological change and diversity of periodontium and alveolar bone after tooth transplantation into artificial tooth socket. Methods: 6 dogs were divided randomly into 2 groups: 2 dogs were used as the controls and 4 used for the experiment. In the control group 4 teeth were autotransplanted into the inherent sockets. In the experiment group 4 teeth were autotransplanted into the artificial sockets. The dogs were sacrificed at the 16th week after operation. The healing condition of periodontal tissue and the remodeling of alveolar bone were examined. Results: None of the transplanted teeth in both groups was loosen or dropped. Mircro-CT examination showed that cancellous bone and bone trabecula around the transplanted teeth lined tightly,no significant difference of bone trabecula thickness was observed between the 2 groups. Hard tissue slice examination revealed that parodontium of both groups grew and adhered to the teeth,and the quantity of new-born bone between the top of alveolar ridge and the neck of transplanted teeth was fundamentally the same in the 2 groups. Conclusion: Autotransplantation of teeth into the artificial socket is similar to that into inherent socket.%目的: 研究自体牙移植到人工牙槽窝后牙周愈合及牙槽骨组织形态改变.方法: 选取12个月龄杂种犬6只,随机编号分为2组,对照组(2只鼠4颗牙): 将自体牙移植到固有牙槽窝.实验组(4只鼠4颗牙): 将自体牙移植到人工牙槽窝.牙移植术后16周后,处死实验犬,切取移植牙及其周围约1 cm的骨块,显微CT检查、硬组织切片观察牙周愈合与周围牙槽骨改建情况,评价牙周膜愈合及牙槽骨的质和量.结果: 术后16周,实验组和对照组移植牙无异常松动,无脱落.显微CT显示: 实验组移植牙牙周膜间隙存在,牙根无吸收,实验组与对照组的牙槽骨等数据分析无统计学意义.硬组织切片形态学显示: 实验组与对照组的移植牙周膜再附着形成,其牙根尖与根周部分的新生骨量基本相同.结论: 自体牙移植到人工牙槽窝与移植到自体牙槽窝后愈合效果相似.

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