阿尔茨海默病、血管性痴呆及轻度认知障碍患者血浆脑源性神经营养因子浓度变化

摘要

目的:探讨阿尔茨海默病(AD)、血管性痴呆(VD)、轻度认知障碍(MCI)与血浆脑源性神经营养因子(BDNF)的关系.方法:以50例MCI、45例AD、30例VD患者和40名健康老人(对照组)为研究对象,用酶联免疫吸附测定法检测血浆BDNF浓度.结果:对照组(6.4±3.1) μg/L、MCI组(6.2±5.1).μg/L、AD组(8.1±5.0) μg/L及VD组(5.6±4.8) μg/L BDNF浓度差异有统计学意义(P=0.013),且AD组BDNF浓度显著高于MCI及VD组(均P＜0.05).轻、中重度AD及MCI组间BDNF浓度差异有统计学意义(P=0.023).未发现各组BDNF浓度与性别、年龄、病程、卒中次数、MMSE评分、CDR评分及ADL评分有显著相关关系.结论:AD患者血浆BDNF浓度显著高于MCI及VD患者,但三者BDNF水平与病程及认知功能损害变化无关.%Objective To investigate the relation of alzheimer disease (AD),vascular dementia (VD) and mild cognitive impairment (MCI) with plasma brain-derived neurotrophic factor (BDNF).Methods All subjects included 50 MCI,45 AD,30 VD and 40 healthy elderly.The concentration of BDNF were tested by enzyme-linked immunosorbent assay (ELISA).Results BDNF concentrations were significant different in MCI group (6.2 ± 5.1)μg/L,AD group (8.1 ± 5.0) μg/L,VD group (5.6 ± 4.8) μg/L,compared with control group (6.4 ± 3.1) μg/L (P =0.013),and BDNF concentrations in AD group was higher than MCI and VD groups (P ＜ 0.05).There were significant differences between moderate-to-severe AD group and MCI group (P =0.023).There were no significant correlation between BDNF concentration and gender,age,duration,stroke frequency,MMSE score,CDR score and ADL score in all groups.Conclusions Plasma BDNF concentration in AD group were higher than MCI and VD groups,but BDNF concentration were not related with the course of disease course and cognitive impairment in the three groups.