椎管内注射治疗膝骨性关节炎合并退行性腰椎病变的疗效观察

摘要

Objective To observe the efficacy of epidural injection in patients with both knee osteoarthritis (KOA) and degenerative lumbar spine disease (DLSD). Methods 50 patients with both KOA and DLSD (Group A) were divided into Group Al and Group A2, another 50 patients with KOA (Group B) were divided into Group Bl and Group B2. Patients in Group Al and Bl received local injection in knee after lumbar epidural injection, and those in Group A2 and B2 received local injection in knee only. The visual analogue scale (VAS) and Lysholm scale in each groups before and 1 day, 2 months and 6 months after treatment were recorded. Results The therapeutic effect in Group Al was significantly better than that in Group A2 (P < 0.001) until 6 months after treatment (P < 0.01). The therapeutic effects of lumbar epidural injection for knee osteoarthritis were significant in Group Bl and B2 (P < 0.001) , but there was no statistically differences between the two groups (P > 0.05). Conclusion There was significant therapeutic effect of epidural injection on patients with both KOA and DLSD.%目的:观察椎管内注射治疗膝骨性关节炎(KOA)合并退行性腰椎病变(DLSD)的临床疗效.方法:合并DLSD和单纯KOA患者各50例,分为A1、A2和B1、B2组.A1和B1组:先腰部硬膜外注射治疗,再行膝关节治疗;A2和B2组:单纯膝关节治疗.治疗前、治疗后1 d、2个月、6个月进行VAS和Lysholm评分.结果:A1组硬膜外注射治疗效果显著(P<0.001),2个月和6个月后效果仍显著优于A2组(P<0.01).B2组硬膜外注射治疗效果不明显(P>0.05);B1和B2组均对膝关节治疗效果显著(P<0.001).但组间比较差异无显著性(P>0.05).结论:椎管内注射治疗可以显著提高KOA合并DLSD的临床疗效.