Objective To observe nasal resistance in healthy adult people and patients with obstructive sleep apnea hypopnea syndrome (OSAHS), comparing the changes in nasal resistance after nCPAP treatment, and to explore the role of nasal resistance in development of OSAHS and the effect of nCPAP on nasal resistance. Methods Detection of nasal resistance was performed in 11 healthy people and 40 patients with OSAHS after completion of polysomnography (PSG). Three weeks after treatment with nCPAP, the patients received polysomnography and detection of nasal resistance again. Results Nasal resistance was higher in patients with OSAHS than healthy people [(0.27 ± 0.9)Pa/(cm3·s) vs. (0.21 ± 0.7)Pa/(cm3·s), t=-2.048, and P<0.05];nasal resistance was not related with age, BMI, neck circumference, waistline, AHI, MinSO2, and ODI (P>0.05). MinSO2, AHI and ODI were markedly improved three weeks after nCPAP therapy (P<0.05). Nasal resistance was increased from (0.27 ± 0.1) Pa/(cm3·s) to (0.43 ± 0.3)Pa/(cm3·s) after treatment (t = -2.733, P < 0.05). Conclusions Increased nasal resistance is one of risk factors for pathogenesis of OSAHS. Nasal resistance is not related with the severity of OSAHS. nCPAP can lead to an elevation in nasal resistance.%目的：观察正常成人与阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的鼻阻力，比较OSAHS经鼻气道内正压通气（nCPAP）治疗前后鼻阻力的变化，探讨鼻阻力在OSAHS发病中的作用及nCPAP治疗对OSAHS鼻阻力的影响。方法：对11名健康对照者及40例OSAHS患者在完成多导睡眠图（PSG）监测的基础上行鼻阻力测定，OSAHS患者nCPAP治疗3周后复测多导睡眠监测及鼻阻力。结果：OSAHS组鼻阻力为（0．27±0．9）Pa／（cm3·s），高于健康对照组（0．21±0．7）Pa／（cm3·s）（t＝－2．048，P＜0．05），鼻阻力与年龄、体质指数（BMI）、颈围、腰围、呼吸暂停低通气指数（AHI）、最低血氧饱和度（MinSO2）和氧降指数（ODI）无相关关系（P＞0．05）。中重度OSAHS患者经nCPAP治疗3周后显著改善MinSO2，AHI及ODI（P＜0．05），而治疗后鼻阻力由（0．27±0．1）Pa／（cm3·s）升高到（0．43±0．3）Pa／（cm3·s）（t＝－2．733，P＜0．05）。结论：鼻阻力增加是OSAHS的发病危险因素之一，而鼻阻力大小与OSAHS的严重程度无关。 nCPAP治疗后可导致鼻阻力升高。
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