ADIPOQ基因11377C/G位点多态性与身体活动对儿童代谢综合征的影响

摘要

目的:探讨ADIPOQ基因多态性位点11377C/G rs266729 与身体活动的交互作用对儿童代谢综合征的影响. 方法: 采用病例对照研究的方法, 病例组 114 例, 对照组 114 例. 应用直接测序法检测ADIPOQ 11377C/G 的基因型,用叉生分析方法研究其与身体活动的交互作用对代谢综合征的影响. 结果:活动充分是代谢综合征的保护因素,OR值为0.14;身体活动不足与11377C/G CC 基因型存在交互作用,可以增加儿童代谢综合的风险.结论:身体活动充分可以降低儿童患代谢综合征的风险.身体活动与11377C/G rs266729多态性对儿童代谢综合征存在交互作用.%Objectve To study the effect of interaction between ADIPOQ 11377C/G (rs266729) gene polymorphism and physical activity in metabolic syndrome in children. Methods We conducted a case-control study in 114 cases and 114 controls. The genotype of ADIPOQ 11377C/G had been detected in direct sequenc-ing. The effect of interaction between gene polymorphism and physical activity was evaluated by a crossover analysis. Results Efficient physical activity was a protective factor (OR = 0.14); there was interaction between inefficient physical activity and CC genotype of 11377C/G which was a risk factor for metabolic syndrome in children. Conclusion Efficient physical activity can reduce the risk of metabolic syndrome in children. There was interaction between 11377C/G (rs266729) polymorphism and physical activity.