中国人群脂联素基因启动子区-11377C/G位点多态性与2型糖尿病易感性的Meta 分析

摘要

目的 探讨中国人群脂联素基因启动子区-11377C/G位点多态性与2型糖尿病易感的相关性.方法 检索2011年11月前中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、万方数据库、维普中文科技期刊数据库(VIP)及Medline、Cochrane Library、Embase、Springer、Ovid等数据库,收集有关中国人群脂联素基因-11377C/G多态性与2型糖尿病的相关性研究;评价纳入研究质量,提取有效数据,采用Review Manager5.0软件进行Meta分析.结果 共纳入12组研究中国人群脂联素基因启动子区-11377C/G位点多态性与2型糖尿病的相关性的病例-对照研究,2型糖尿病病例2 598例,对照4 508例.Meta分析发现,脂联素基因启动子区-11377C/G位点C/G多态性与2型糖尿病相关性中G等位基因与C等位基因[OR=1.14,95%CI(1.03,1.25),P=0.009]、基因型(CG+GG)与CC[OR=1.19,95%CI(1.06,1.35),P=0.004]、基因型CG与CC[OR=1.14,95%CI(1.00,1.29),P=0.05]、基因型GG与CC[OR=1.34,95%CI(1.06,1.71),P=0.02]均具有统计学意义差异.结论 中国人群脂联素基因启动子区-11377C/G位点多态性与2型糖尿病易感性存在相关性.%Objective To investigate the association between the polymorphism of -11377C/G sites in adiponectin gene and type 2 diabetes mellitus (T2DM) in Chinese Population. Methods Data in PubMed, Embase, Cochrane Library, Springer, Ovid,CNKI, VIP and Wanfang Database were retrieved before November 2011,cases studies on association between adiponectin gene pol ymorphism-11377C/G sites and T2DM in Chinese Population were collected. Quality of included studies were evaluated,and valid data were extracted and analyzed by Review Manager5. 0 software for Meta analysis. Results Twelve case control studies on adi ponectin gene -11377C/G site,involving 2 598 patients of T2DM and 4 508 controls. The results of Meta analysis showed that,of the correlation of adiponectin gene -11377C/G site polymorphism and T2DM,there was significance different between G allele and C allele[QR = l. 14,95 %CI (1. 03- 1. 25) , P = 0. 009] , genotype (CG + GG) and CC[QR = 1. 19 , 95% CI(1. 06 - 1. 35 ) ,P = 0.004],genotype CG and CC[QR = 1. 14 ,95%CI(1. 00-1. 29) ,P = 0. 05] ,and genotype GG and CC[QR = 1. 34,95%CI(1. 06-1. 71) ,P = 0. 02]. Conclusion Adiponectin gene polymorphism -11377C/G site might be associated with susceptibility of T2 DM in Chinese Population.