目的 探讨中国人群脂联素基因+276G/T位点多态性与2型糖尿病(T2DM)的相关性.方法 检索2011年8月前中国知网、维普中文科技期刊全文数据库、中国万方数据库、中国学位论文全文数据库和中国重要会议论文全文数据库及Medline、Cochrane Library、Embase、Springer、Ovid等数据库,收集有关中国人群脂联素基因+276G/T位点多态性与T2DM相关性研究的文献;评价纳入研究质量,提取有效数据,采用Review Manager 5.0软件进行Meta分析.结果 共纳入11项研究中国人群脂联素基因+276G/T位点多态性与T2DM相关性的病例对照研究;T2DM患者1 697例,健康对照者1 341例.Meta分析结果显示,脂联素基因+276G/T位点G/T多态性与T2DM的相关性中T等位基因与G等位基因(OR=0.83,95% CI为0.65～1.05,P=0.12)、基因型(GT+TT)与GG(OR=0.82,95% CI为0.60～1.12,P=0.20)、基因型GT与GG(OR=0.93,95%CI为0.63～1.38,P=0.72)、基因型TT与GG(OR=0.81,95%CI为0.46～1.42,P=0.46)比较,差异均无统计学意义.结论 中国人群脂联素基因+276G/T位点多态性可能与T2DM易感性无关.%Objective To investigate the association between the polymorphism of adponectin gene + 276G /T site and type 2 di-abetes m ellitus(T2DM ) in Chinese population.M ethods Literatures, related with correlation research on adiponectin gene poly-m orphism + 276G /T site and T 2D M in C hinese population , w ere retrieved in databases including CN K I, V IP , W anfang D atabase, CDDB , CPFD , M edline, Cochrane Library, Embase, Springer and Ovid before August 2011. The quality of enrolled researches w as evaluated and valid data w ere extracted . M eta analysis w as perform ed by using R eview M anager 5 .0 softw are .Results E leven case-control researches on correlation between adiponectin gene +276G/T site polymorphism and T2DM in Chinese population were enrolled, involving 1 697 patients with T2DM and 1 341 controls. M eta analysis indicated that, according to the correlation with T2DM , therewasno statistical difference betw een T alleleandG allele(OR=0 .83 , 95% Clfor0 .65-1.05 , P=0.12),gen-otype of (GT+TT ) and GG (0R=0 .82 , 95% CI for 0.60-1.12, P=0.20), genotype of GT and GG (OR = 0 .93 , 95% CI for 0.63-1.38, P=0.72),and genotype of TT and GG (0R = 0 .81, 95% CI for 0.46 - 1.42, P=0.46).Conclusion Adponectin gene+276G /T site polym orphism m ight be not associated w ith T 2D M in C hinese population .
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