Objective To determine whether concentrations of plasma homocysteine and status of folate and vitamin B12 were altered in patients with heroin dependence compared with control subjects. Methods We recruited 20 patients with heroin addiction. Twenty age-and sex-matched healthy volunteers as the control group were enrolled. Blood concentrations of homocysteine, folate and vitamin B12 were measured in a fasted status. Results Mean homocysteine level was higher in the heroindependence group than in the control group [18.3 ± 4.5 (Q1 = 14.7, Q2 = 17.6, Q3 = 19.2) vs. 8.4 ± 2.7 (Q1 = 5.9, Q2 = 8.5, Q3 = 10.5) μmol/L, P < 0.001]. Patients in heroinaddictiongroup had signi cantly lower folate levels compared with the control group [6.6 ± 2.6 (Q1=4.6, Q2=6.4, Q3=8.1) vs. 12.7 ± 2.5 (Q1 = 11.1, Q2 = 13.0, Q3 = 17.5) ng/mL, P < 0.001]. There was significant difference on plasma B12 concentrations between heroin users and controls [384.1 ± 228.8 (Q1=312.0, Q2=348.5, Q3=374.5) vs. 399.4 ± 45.1 (Q1=358.0, Q2=394.5, Q3=428.3) Pg/mL, P < 0.001]. Heroin users group demonstrated a negative correlation of homocysteine with folate , which was statistically significant in heroin users groups (r = - 0.614; P = 0.004), there was a trend towards a negative correlation of homocysteine with B12 in heroin users (r = -0.605; P = 0.005), respectively. Conclusions We conclude that patients with heroin dependence are prone to high concentration of plasma homocysteine.%目的：研究海洛因依赖对人体血清同型半胱氨酸（Hcy）水平的影响。方法：根据入选标准收集住院的海洛因依赖患者20例为病例组；同期健康体检者20例为对照组，检测两组空腹状态下血清 Hcy 酸、叶酸、维生素B12（VitB12）水平。结果：病例组血清Hcy 水平显著高于对照组[18．3±4．5（Q1＝14．7， Q2＝17．6， Q3＝19．2）mmol／L vs．8．4±2．7（Q1＝5．9， Q2＝8．5， Q3＝10．5）μmol／L， P ＜0．001]。病例组血清叶酸水平显著低于对照组[6．6±2．6（Q1＝4．6， Q2＝6．4， Q3＝8．1） ng／mL vs．12．7±2．5（Q1＝11．1， Q2＝13．0，Q3＝17．5） ng／mL， P ＜0．001]。病例组血清 VitB12水平显著低于对照组[384．1±228．8（Q1＝312．0，Q2＝348．5， Q3＝374．5） pg／mL vs．399．4±45．1[Q1＝358．0， Q2＝394．5， Q3＝428．3] pg／mL， P＜0．001）。病例组血清Hcy与叶酸、VitB12水平存在负相关（r ＝－0．614，P ＝0．004； r ＝－0．605， P ＝0．005）。结论：海洛因依赖可导致人体血清同型半胱氨酸水平升高。
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