目的：研究乳腺癌组织芯片中驱动蛋白Kif2a的表达及临床意义。方法：采用组织芯片技术及免疫组织化学方法检测102例乳腺癌及癌旁组织中Kif2a的表达。对有随访结果的62例作单因素、多因素相关生存分析。结果：乳腺癌组织与癌旁组织中Kif2a的表达比较差异有统计学意义。 Kif2a在乳腺癌中的表达与淋巴结转移、HER2表达呈正相关（P ＜0．05）。在随访的62例中，单因素分析显示：乳腺癌中 Kif2a 表达、淋巴结转移、HER2表达均与患者生存率有关，多因素 Cox 比例风险分析显示均具有独立的预后意义。结论：Kif2a在乳腺癌组织中的表达与淋巴结转移、HER2表达呈正相关（P ＜0．05）。 Kif2a表达水平的检测对乳腺癌的预后判断具有重要意义。%Objective To study the expression and clinical significance of Kif2a in breast carcinoma by the application of tissue microarray. Methods Tissue microarray and immunohistochemistry method (S-P) were used to examine the expression of Kif2a in 102 cases of breast carcinoma tissue and adjacent tissue. The prognosis of 62 cases followed up were studied by both univariate and multivariate analysis. Results The expression of Kif2a has significant difference between breast carcinoma tissue and adjacent tissue. Kif2a expression were associated with lymph nodal involvement and HER2 expression (P < 0.05). In the 62 cases with followed-up data, univariante analysis revealed that the expression of Kif2a, lymph nodal involvement and HER2 expression were correlated with the survival rate. Cox stepwise proportional hazards analysis showed that they were independently prognostic factors. Conclusions Kif2a expression in breast carcinoma were associated with lymph nodal involvement and HER2 expression (P<0.05). It is meaningful to examine Kif2a expression for prognosis of the breast carcinoma.
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