慢性心力衰竭合并心房颤动患者心型脂肪酸结合蛋白、超敏C反应蛋白及同型半胱氨酸水平的变化

摘要

目的 观察心型脂肪酸结合蛋白(heart type-fatty acid binding protein,H-FABP)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)以及同型半胱氨酸(homocysteine,Hcy)在慢性心力衰竭合并心房颤动患者中的浓度变化,探讨其在房颤发生发展中的临床意义.方法 将85例心衰合并房颤患者根据NYHA心功能分级分为Ⅱ、Ⅲ、Ⅳ级,并选取78例心功能正常的窦性节律者为对照组.分别检测各组患者的H-FABP、hs-CRP以及Hcy浓度.结果 与对照组相比,房颤患者的H-FABP、hs-CRP以及Hcy浓度明显升高(P<0.05);且随着心功能分级的增加,这三种标记物的浓度也逐渐增加(P<0.05).结论 H-FABP、hs-CRP以及Hcy与房颤发生、维持及心肌细胞的损伤密切相关;且与房颤患者的心衰的严重程度相关.%Objective To investigate the level changes and clinical value of serum H-FABP,hs-CRP and Hcy in patients with atrial fibrillation(AF)and chronic heart failure(CHF).Methods 120 patients with AF and CHF were chosen as the observation group,100 patients with sinus rhythm were chosen as the control.The levels of H-FABP,hs-CRP and Hcy of the two groups were compared.H-FABP,hs-CRP and Hcy levels were also compared in the different subgroups divided according to the cardiac function.Risults Compared with the control group,the levels of H-FABP,hs-CRP and Hcy in patients with atrial fibrillation were significantly higher(P<0.05).The lev-els of H-FABP,hs-CRP and Hcy in the observation group were higher than those in the control group in the same cardiac function subgroup(P < 0.05). Conclusion The elevation of the level of H-FABP,hs-CRP and Hcy are closely related to the occurrence and maintenance of atrial fibrillation and the damage of myocardial cells,and it was related with the severity of cardiac function.