产后抑郁症和性激素水平、神经递质之间的相关性分析

摘要

Objective To explore the correlation on serum sex hormones levels,neural transmitter and the patients with postpartum depression.Methods 80 cases of patients with postpartum depression were the obser-vation group,80 cases of maternal health were the control group.The scores of EPDS,HAMD,HAMA,the levels of E2,PRL,P,5-HT,DA,NE,OFQ were compared.Results The scores of EPDS,HAMD,HAMA for the ob-servation group were higher than the control group(P<0.05).There had significant difference on the levels of E2, PRL,P(P < 0.05). There had significant difference on the levels of 5-HT,DA,NE,OFQ on postpartum 2 d, 1 week for the two groups(P<0.05).It had positive correlation on EPDS,scors,PRL,P,OFQ(r=0.496,r=0.417,r=0.505,P<0.05).It had negative correlation on EPDS,E2,5-HT,DA,NE(r=-0.597,r=-0.583, r =-0.517,r =-0.422,P < 0.05). Conclusions It significantly related on serum sex hormones levels,neural transmitter and the patients with postpartum depression,and it can predict and prevent postpartum depression by early detection the levels of serum sex hormones levels,neural transmitter.%目的 探讨产后抑郁症和性激素水平、神经递质之间的相关性.方法 比较80例产后抑郁症患者和80例健康产妇的EPDS评分、HAMD评分及HAMA评分差异,以及E2、PRL、P、5-HT、DA、NE、OFQ水平差异.结果 观察组EPDS、HAMD和HAMA评分均显著高于对照组(P<0.05);观察组与对照组产后2 d及产后1周E2、PRL、P、5-HT、DA、NE、OFQ水平均存在显著差异(P<0.05);EPDS评分与PRL、P、OFQ呈正相关(r=0.496,r=0.417,r=0.505,P<0.05),与E2、5-HT、DA、NE呈负相关(r=-0.597,r=-0.583, r=-0.517,r=-0.422,P<0.05).结论 产后抑郁症与性激素和神经递质水平的异常改变紧密相关,早期检测产妇性激素和神经递质水平可预测和防范产后抑郁症的发生.