Correlation analysis of Toll-like receptor 3 content in peripheral blood with electroencephalogram parameters and neurotransmitter content in children with intractable epilepsy

摘要

Objective: To detect the content of Toll-like receptor 3 (TLR3) in peripheral blood of childrenwith intractable epilepsy, explore the correlation between TLR3 content and EEG parameters,neurotransmitter contents. Methods: 37 cases of Intractable epilepsy children in our hospitalduring September 2016to June 2018 were chosen as Intractable epilepsy group, 30 casesof healthy volunteers who underwent physical examination in our hospital were treated asNormal control group. The levels of TLR3, neurotransmitter [5-hydroxytryptamine (5-HT),dopamine (DA), epinephrine (E), norepinephrine (NE)] and electroencephalogram parameters[alpha, beta, delta, theta] in peripheral blood of two groups were compared. Pearson test wasused to evaluate the correlation of TLR3 content in peripheral blood with EEG parametersand neurotransmitter content in children with intractable epilepsy. Results: Content of TLR3in peripheral blood of Intractable epilepsy group was significantly higher than that of Normalcontrol group; the alpha power and theta power of EEG parameters were lower than thoseof Normal control group; contents of neurotransmitters such as 5-HT, DA, E and NE weresignificantly lower than those of Normal control group (P0.05). Conclusion: The abnormalincrease of TLR3 in peripheral blood of children with intractable epilepsy may be one of thedirect causes of neurological impairment in children with intractable epilepsy.