TACE联合三维适形放疗治疗中晚期原发性肝癌疗效观察

摘要

Objective To investigate the clinical effects of transcatheter arterial chemoembolization (TACE) combined with three dimensional ccnformal radiotherapy (3-DCRT)on patients with advanced hepatocellular carcinomaMethods A total of 87 patients with advanced hepatocellular carcinoma were randomly divided into TACE/3-DCRT g-oup (n=45) and TACE g-oup (n=42).The patients in TACE/3-DCRT g-oup were treated first with TACE and then 3-DCRT,the dose was 2.6~3.2Gy each time, and the total dose was 48~60Gy. The patients in TACE group were gven TACE only.Results The total response (CR+PR) were 86.7% in TACE/3- DCRT group, much higher than 66.7% in TACE group (P＜0.05);The 1,2,3-year survival rates were 73.3%,53.3%,35.6% and 59.5%, 31.0%, 14.3%, respectively in the two groups.Conclusions TACE combined with 3-DCRT is mere effective than TACE only, and the side effects are tolerated.%目的 探讨肝动脉灌注栓塞化疗(TACE)联合三维适形放疗(3-DCRT)治疗中晚期原发性肝癌的疗效.方法 87例患者随机分为TACE联合3-DCRT治疗组45例和TACE治疗组42例.联合组先进行TACE治疗1～2次,4～6周后行3-DCRT,分割剂量2.6～3.2 Gy,总剂量为 48～60 Gy.TACE组行TACE治疗2～3次.结果联合组近期总有效率为86.7 %,TACE组为66.7% (P<0.05);两组1年、2年、3年生存率分别为73.3%、53.3%、35.6%和59.5%、31.0%、14.3%,其中2、3年生存率差异具有统计学意义(P<0.05).结论 TACE联合3-DCRT治疗中晚期原发性肝癌具有较好的疗效,不良反应少.