目的 探讨非酒精性脂肪性肝炎(NASH)的临床特征及其危险因素.方法 选取NASH患者76例和健康人84例,分析临床症状、生化和影像学指标.结果 在76例患者中,体检发现者43例(56.6%),有症状者33例(43.4%);NASH组BMI、DBP、FPG、2hPPG、TG、ALT、ALT/AST、CRP、PLT与对照组比较有显著性差异(P＜0.05);与NASH关系最密切的指标是BMI(OR=8.45),其次分别是TG、2hPPG、FPG、DBP、年龄、病程(OR分别为3.70,2.83,2.61,2.10,1.41、1.20).结论 NASH患者起病隐匿,多无明显的消化道症状,肥胖、高脂血症、糖尿病和高血压是发生NASH的主要危险因素.%Objective To investigate the clinical features and main risk factors in nonalcoholic steatohepatitis (NASH). Methods A total of 76 patients with NASH and 84 healthy subjects were included. The clinical symptoms,biochemical and image index were analyzed. Results In 76 patients with NASH,43 patients (56.6％)had no and 33 patients (43.4％)had gastrointestinal symptoms;there were significant differences in BMI, DBP, FPG,2hPPG, TG,ALT,ALT/AST,CRP and PLT between patients with NASH and control group (all P＜0.05);logistic regression analysis showed that BMI (OR=8.45)was highly related to NASH and TG,2hPPG,FPG,DBP,age were all involved (OR =3.70, 2.83, 2.61, 210, 1.41). Conclusions Patients with NASH had no obvious gastroenterology symptoms. Obesity, hypertension, diabetes and hyperlipemia are important risk factors of NASH.
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