Objective To prevent the side effects of the Vitamin K1 Injection with the individual intervention care to the infant patients administered the injection. Methods Every infant patient was administered the dilute injection through the intravenous drip and the drug allergy history was registered. 107 infant patients administered Vitamin K1 Injection during January 1,2014 to December 31,2014 were chose as the research participants,who were randomly divided into control group (52 cases)and interventional group(55 cases). The patients in control group received the routine treatment of transfusion and careful observation,while the infants who had the first treatment and unclear history in the interventional group cannot get Vitamin K1 Injection except those who would have the negative results of allergy skin test. Results 3 anaphylactic reac-tions occurred in control group,whereas no allergy was observed in interventional group(P < 0. 05). Conclusion The indi-vidual intervention care to the infant patients administered Vitamin K1 Injection can provide the efficient prevention of ana-phylactic reactions and ensure the drug use. Furthermore,the harmonious doctor - patient relationship would come true and there would be much less medical disputes.%目的：通过对应用维生素 K1注射液的患儿实施个体化干预措施，来预防药物不良反应的发生。方法应用维生素 K1注射液患儿均采用稀释后静脉滴注方法给药，两组患儿在接受此药物前均进行药物过敏反应登记。将2014年1月1日～2014年12月31日使用维生素 K1注射液治疗的患儿107例作为研究对象，随机分为对照组52例和干预组55例。对照组仅给予常规输液治疗及严密观察，干预组对初次使用和不清楚用药史的患儿给予药物过敏实验，皮试结果为阴性方可输液治疗。结果对照组有3例发生过敏反应，干预组无过敏反应发生，两组结果的差异有统计学意义（P ＜0.05）。结论对应用维生素 K1注射液治疗的患儿实施个体化干预措施可有效预防药物过敏反应，保障用药安全，促进医患和谐，减少医患纠纷的发生。
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