Objective To explore the effect of valsartan on patients with hypertension and non-alcoholic fatty liver disease ( NAFLD). Methods A total of 148 patients suffered hypertension and NAFLD were included in the study. Patients were divided into the observed group the compared group, which were given valsartan and amlodipine respectively. The difference of the blood pressure, liver ultrasound, liver function, serum lipids, insulin resistance index ( RI ) and clinical curative effect were compared between the two groups. Results The curative effect in the observed group (93.24% ) was significantly higher than that in the compared group (81.08% ) ; After treatment, the alanine aminotransferase, cholesterol, triglyceride, low density lipoprotein and RI in the observed group were significantly lower than that in the compared group(P＜0. 05＝. Conclusion The valsartan had a good effect on patients suffered hypertension and NAFLD.%目的 探讨缬沙坦胶囊治疗伴有非酒精性脂肪肝( NAFLD)的高血压患者的疗效.方法 将符合纳入标准患者随机分成试验组和对照组.试验组给予缬沙坦胶囊；对照组给予氨氯地平片.比较两组血压、肝脏超声、肝功能、血脂、胰岛素抵抗指数(RI)的差别及临床疗效.结果 缬沙坦胶囊组总有效率(93.24％)显著高于对照组(81.08％),差异有统计学意义(x2=4.891,P=0.027)；治疗后,试验组谷丙转氨酶、胆固醇、甘油三酯、低密度脂蛋白及RI均显著低于对照组,差异有统计学意义(P＜0.05).结论 缬沙坦胶囊治疗伴有NAFLD的高血压患者具有更好疗效.
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