早期血液灌流对老年急性有机磷中毒的临床疗效分析

摘要

目的：分析早期血液灌流（hemoperfusion，HP）对老年急性有机磷中毒的临床疗效。方法：收集2009年1月至2014年1月在我院接受治疗的老年急性有机磷中毒的患者76例；依据患者接受 HP 的时间，将76例患者分为观察组（≤8 h）及对照组（＞8 h），分别为37例和39例。结果：观察组患者痊愈率显著高于对照组（χ2＝4．214，P ＝0．040）；观察组死亡率显著低于对照组（χ2＝5．074，P ＝0．024）；观察组患者发生 ARDS 的比例显著低于对照组（χ2＝4．116，P ＝0．043）；入院3 d 以后，观察组患者全血 AChE 活力显著高于对照组（P ＜0．01）。结论：HP 对老年急性有机磷中毒的临床疗效可靠，且早期实施治疗可进一步提高疗效。%Objective:To analyse clinical effect of early hemoperfusion(HP)on acute organophosphorus poisoning in elderly patients.Methods:76 cases of senile acute organophosphorus poisoning in our hospital from January 2009 to January 2014 were select-ed;According to the time of receiving HP,76 cases was divided into observation group(≤8 h,37 cases)and control group(>8 h,39 cases).Results:The cure rate of the observation group was significantly higher than that of the control group(χ2 =5.074,P =0.024);The mortality of the observation group was significantly lower than that of the control group(χ2 =5.074,P =0.024);the proportion of ARDS in the observation group was significantly lower than that in the control group(χ2 =4.1 16,P =0.043);3 days after admission, the AChE activities in blood of the observation group was significantly higher than that of the control group(P <0.01 ).Conclusion:The Clinical effect of HP on senile acute organophosphorus poisoning is reliable,and the efficacy can be improved with early implemen-tation.