肼苯哒嗪、洋地黄、氧疗联合治疗对妊高症并发心衰患者的心脏功能和血浆脑钠肽、醛固酮的改善作用

摘要

目的:探究肼苯哒嗪、洋地黄、氧疗联合治疗对妊高症并发心衰患者的心脏功能和血浆脑钠肽、醛固酮的改善作用.方法: 选取148例妊高症合并心力衰竭的患者,根据数字表法随机分为对照组和观察组,每组各74例;对照组采取常规治疗氧疗法和洋地黄,观察组在对照组基础上给于肼苯哒嗪治疗.结果: 治疗前两组血压[收缩压(SBP)和舒张压(DBP)]均无显著差异(P＞0. 05),治疗后观察组改善程度显著高于对照组(P＜0. 05).疗效比较显示,观察组总有效率为86. 49% ,对照组为59. 46% ,观察组显著高于对照组(P＜0. 05);治疗前两组VE/VA、LVEF和Tei指标均无显著差异(P＞0. 05),治疗后观察组改善程度显著高于对照组(P＜0. 05);LVEDVI、LVESVI、LVEDD、IVST和LVPWT指标比较显示,治疗后观察组的改善程度均显著高于对照组(P＜0. 05).治疗前两组患者BNP、ALD指标无显著差异(P＞0. 05),治疗后观察组显著高于对照组(P＜0. 05).结论: 肼苯哒嗪、洋地黄、氧疗联合治疗在妊高症并发心衰患者的治疗中能有效改善患者心脏功能指标和左心室形态同时,降低血浆脑钠肽和醛固酮水平.%Objective:To explore the effect of hydralazine,digitalis and oxygen therapy in the treatment of patients with pregnan-cy induced hypertension complicated with heart failure cardiac function and plasma brain natriuretic peptide and aldosterone. Methods:148 cases of pregnancy induced hypertension complicated with heart failure patients,according to randomly divided into control group and observation group,74 cases in each group. The control group was treated with conventional therapy oxygen therapy and digitalis. The observation group was given the treatment of hydrazine on the basis of the control group. Results:Before treatment,there was no signifi-cant difference in blood pressure (SBP and DBP) between the two groups (P＞0. 05). After treatment, the improvement of the obser-vation group was significantly higher than that of the control group (P＜0. 05). Comparison of curative effect,the total efficiency of the observation group was 86. 49% ,59. 46% in the control group,the observation group was significantly higher than the control group (P＜0. 05). Before treatment,two groups of VE/VA,LVEF and Tei had no significant difference (P＞0. 05),after treatment, the ob-servation group improved significantly more than the control group (P＜0. 05). LVEDVI,LVESVI,LVEDD,IVST and LVPWT index comparison showed that after treatment,the improvement degree of the observation group were significantly higher than those in control group (P＜0. 05). There was no significant difference in BNP and ALD indexes between the two groups before treatment (P＞0. 05). After treatment,the observation group was significantly higher than that of the control group (P＜0. 05). Conclusion:Hydralazine,digi-talis and oxygen therapy treatment can effectively improve the heart function index and left ventricular morphology and decrease of plas-ma brain natriuretic peptide and aldosterone levels in patients with pregnancy induced hypertension complicated with heart failure.