Objective: To compare lansoprazole and omeprazole, respectively, with the effect of antibiotic treatment of peptic ulcer and security. Methods: 100 cases of peptic ulcer patients from February 2014 to February 2015, were randomly divided into two groups,50 cases of each group. The control group received omeprazole, amoxicillin and clarithromycin combination therapy, observation group received lansoprazole, amoxicillin and clarithromycin combination therapy. Treatment effects, Hp eradication rate and adverse reactions of the two groups were observed. Results: The treatment total effective rate and Hp eradication rate of observation group were 96.0%, 84.0%, both significantly higher than the control group 78.0 and 64.0%(P<0.05). The observation group incidence of adverse reactions were 12.0%, and control group was 14.0%, there was no statistical significance (P>0.05). Conclusion: Peptic ulcer medication, lansoprazole combined with antibiotic regimens were satisfactory, can effectively promote patient recovery, and less adverse drug reactions, worthy of clinical promotion and application.%目的：比较兰索拉唑与奥美拉唑分别配合抗生素治疗消化性溃疡的效果与安全性。方法：将2014年2月～2015年2月100例消化性溃疡患者，随机分为两组，每组50例。对照组采取奥美拉唑、阿莫西林与克拉霉素联合治疗方案，观察组采取兰索拉唑、阿莫西林与克拉霉素联合治疗方案。观察两组治疗效果、Hp根除率以及不良反应。结果：观察组治疗总有效率与Hp根除率分别为96.0%、84.0%，明显高于对照组的78.0和64.0%（P＜0.05）。观察组不良反应发生率为12.0%，与对照组的14.0%对比差异无统计学意义（P＞0.05）。结论：在消化性溃疡临床用药中，兰索拉唑联用抗生素方案疗效满意，可有效促进患者恢复，且较少药物不良反应，值得临床推广。
展开▼
