Objective: To study clinical observation points and analysis of patients with primary open angle glaucoma eye drug treatment and effective nursing intervention measures. Methods: to collect the primary open angle glaucoma patients with a total of 85 cases(162 eyes), were randomly divided into observation group and control group, each 81 cases, patients in the control group were treated with travoprost, patients in the observation group received timolol, brinzolamide combined treatment, and nursing intervention randomly selected two groups of a total of 45 patients, the clinical effect of the two groups were observed and compared. Results: the observation group of patients with intraocular pressure after six months treatment compliance rate was significantly higher than the control group , patients in the observation group treatment compliance rate of intraocular pressure after 1 years was significantly higher than that in control group, patients in the observation group nursing intervention for half a year and 1 years after the intraocular pressure compliance rate were significantly higher than the control group,(P was <0.05). Conclusion: in the treatment of primary open angle glaucoma patients, combination therapy with travoprost, timolol and brinzolamide, can effectively improve the treatment effect, while the patients after the nursing intervention, drug treatment effect is improved effectively, and is worthy of popularization and application.%目的：研究和分析原发性开角型青光眼患者进行药物治疗时的临床观察要点及有效的护理干预措施。方法：收集原发性开角型青光眼患者共85例（162只眼），随机分为观察组与对照组，各81只眼，对照组患者使用曲伏前列素进行治疗，观察组患者在此基础上接受噻吗洛尔、布林佐胺的联合治疗，并随机抽取两组共45名患者进行护理干预，将两组患者的临床效果进行观察和对比。结果：观察组患者治疗半年后的眼压达标率明显高于对照组，观察组患者治疗1年后的眼压达标率显著高于对照组患者，观察组患者实施护理干预半年和1年后的眼压达标率均明显高于对照组，（P均<0.05）。结论：在原发性开角型青光眼患者的治疗过程中，使用曲伏前列素、噻吗洛尔和布林佐胺的联合治疗，能够有效提高治疗的效果，而患者在接受了护理干预之后，药物治疗的效果得到了有效提高，值得推广应用。
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