目的 探讨浸润性乳腺癌分子亚型分布及其与临床病理特点的关系.方法 选择2009年9月至2011年8月期间明确诊断的女性浸润性乳腺癌病例267例,分析雌激素受体(ER)、孕激素受体(PR)、HER-2的表达水平,以及乳腺癌分子亚型与临床病理特点的关系.结果 267例中52.0％为Luminal A型,16.5％为Luminal B型,Her-2(+)型占15.4％,Triple Negative型占16.1％.各分子亚型乳腺癌患者年龄集中在55岁以下,发病年龄有年轻化趋势.Luminal A型肿瘤分化程度较高,病理TNM分期偏早,晚期病例少,预后良好；Luminal B型组织学分级以Ⅱ级为主,患者中未绝经者比例高.Her-2(+)型乳腺癌肿瘤趋向于低分化,大长径；Triple Negative型乳腺癌患者诊断时原发肿瘤较大,组织学分级高,腋窝淋巴结转移者较多,具有更多不良预后因素.结论 浸润性乳腺癌分子亚型分布差异存在统计学意义,并与其临床病理特点密切相关.%ObjectiveTo explore the relationship between the molecular subtypes and clinicopathologic fea-tures in patients with invasive breast cancer. Methods267 female cases with invasive breast cancer betweenSept 2009 and Aug 2011 were included in this study. The expression of estrogen receptor ( ER) , progestin re-ceptor ( PR) and HER - 2 were detected and the relationship between molecular subtypes and clinicopatholog-ical features were analyzed. Results The proportions of four molecular subtypes in 267 cases were: luminal A subtype (52. 0% ) , luminal B subtype ( 16. 5% ) , HER - 2 + type ( 15. 4% ) , triple negative type ( 16. 1% ). The age of most patients were less than 55 years. The degree of tumor differentiation of luminal A subtype was higher, whose pathologic TNM stage was earlier, having less end - stage patients and better prog-nosis than those of others. Luminal B subtype was mostly characterized as histological grade II and had high proportion of non - menopausal patients. The HER - 2 + type trended to be poorly differentiated and had large diameter. In patients with triple negative type, the size of primary tumor at diagnosis was larger and histologi-cal grade was higher, while they had more axillary lymph nodes metastasized and more adverse prognosis fac-tors than those of others. Conclusion The molecular subtype distribution of invasive breast cancer varied, which was closely related with clinicopathologic features.
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