目的 探讨缺血性脑卒中患者颈部血管狭窄情况和血流动力学改变,以及血清LDL-C水平变化情况.方法 选取缺血性脑卒中患者60例为观察组,60名健康体检者为对照组,分别进行颈部血管彩色多普勒超声检查和LDL-C检测,比较2 组检查结果的差异.结果 观察组颈动脉狭窄程度大于对照组(P＜0. 01 ),颈总动脉内-中膜厚度、颈总动脉分叉处内-中膜厚度、血管阻力指数及搏动指数均高于对照组(P均 ＜0. 05 ),而收缩期峰值流速及舒张末期流速均低于对照组(P均 ＜0. 01),LDL-C水平高于对照组(P＜0. 01 ).结论 缺血性脑卒中患者的颈动脉粥样硬化程度及血清LDL-C水平与正常人有差异,提示两者可作为缺血性脑卒中患者的常规检查项目以助个体化治疗与二级预防.%Objective To investigate the carotid artery stenosis and hemodynamic changes in patients with ischemic stroke and the changes of serum low-density lipoprotein-cholesterin (LDL-C)levels. Methods Sixty patients with ischemic stroke were assigned into the observation group and sixty healthy individuals receiv-ing physical examination were allocated into the control group. Ultrasonography of the carotid arteries and the detection of LDL-C levels were performed and statistically compared between two groups. Results The severity of carotid artery stenosis in the observation group was significantly higher compared with that in the control group (P＜0. 01). In the observation group,the common carotid artery intima-media thickness,common ca-rotid artery bifurcation intima-media thickness,vascular resistance index,and vascular pulsatility index were markedly higher than those in the control group (all P＜0. 05 ). Doppler findings demonstrated that the peak systolic velocity and the end diastolic velocity of the carotid arteries in the observation group were significantly lower compared with those in the control group (both P＜0. 01). Compare with the control group,the LDL-C level in patients with ischemic stroke was significantly higher (P＜0. 01 ). Conclusions In patients with is-chemic stroke,the severity of carotid artery atherosclerosis and the serum LDL-C level significantly differ from those in the healthy individuals,prompting that they can be utilized as routine examination parameters and con-tribute to individualized therapy and secondary prevention for patients with ischemic stroke.
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