目的 探讨产后抑郁症患者海马区的代谢变化.方法 利用磁共振波谱技术(1H-MRS)检测20名健康产妇和20例产后抑郁症患者的海马头部、体部及尾部的多个代谢指标,包括N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)、肌酸(Cr)、肌醇(MI),并计算NAA、Cho、MI与Cr的比值.结果 产后抑郁症组双侧海马头部、体部NAA/Cr值较对照组减低,差异有统计学意义(P＜0.05),双侧海马尾部NAA/Cr值较对照组无显著变化,差异无统计学意义(P＞0.05).产后抑郁症组双侧海马头、体及尾部Cho /Cr值较对照组无显著变化,差异无统计学意义(P＞0.05).产后抑郁症组双侧海马头部MI/Cr值较对照组减低,差异有统计学意义(P＜0.05);而双侧海马体部及尾部MI/Cr值较对照组无显著变化,差异无统计学意义(P＞0.05).结论 产后抑郁症患者海马部分区域代谢发生改变,此变化可能构成产后抑郁症的神经生物学基础.%Objective To explore the neurochemical changes of the hippocampus in the patients with postnatal depression. Methods A total of 20 postnatal depression patients and 20 postnatal healthy controls were recruited, and the hippocampal head, body and tail were evaluated by magnetic resonance spectroscopy (1H-MRS). The indicators included N-acetylaspartic acid (NAA), choline complex (Cho), creatine (Cr), inositol (MI), and calculated the ratio. Results The values of NAA/Cr in the bilateral hippocampal head, body of the postnatal?depression patients were significantly higher than the health controls (P＜ 0.05), while there was no significant difference in the hippocampal tail between the two groups (P＞0.05). There were no significant differences in the value of Cho /Cr in the hippocampal head, body or tail between the two groups (P＞0.05). The value of MI/Cr in the bilateral hippocampal head of the postnatal depression patients was significantly decreased than the health controls (P＜0.05), while there was no significant difference in the hippocampal tail between the two groups (P＞0.05). Conclusions Metabolism of hippocampus in patients with postpartum depression changes, which may constitute the neurobiological basis of postpartum depression.
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