Objective To detect the metabolism of serum 25-hydroxy vitamin D3(25-OH D3)and other hydroxylated metabo-lites in patients with vitiligo , and also to analyze the relationship between the biological indicator and the pathogenesis of vitiligo . Methods Three milliliters of fasting blood samples were collected from 140 vitiligo patients and 60 healthy controls and separated with an centrifuger at 3 000 rpm for 10 minutes, stored at 4℃and then measured by ELISA .The 25-OH D3 levels of vitiligo patients were divided into 4 grades:the sufficient level of serum 25-(OH)D3(74.1-250.0 nmol/L), the normal level(47.7-74.0 nmol/L), the insufficient level(25.0-47.6 nmol/L) and the deficient level ( <25 nmol/L) .Then, the patients were divided into the youngster group (with an age between 5-18 years) and the adult group (with an age between 19-56 years).The detection results of the young-ster group were compared with those of the control groups with different age ranges and were analyzed with SPSS 13.0.Results For the youngster group with vitiligo, the percentages of the patient populations with sufficient , normal, insufficient and deficient 25-(OH)D3 levels were 0, 7.4%, 59.3% and 33.3% respectively, averaging (30.6 ±10.5) nmol/L, the percentages of the controls were 10.0%, 43.3%, 46.7% and 0 respectively, averaging (50.1 ±12.1)nmol/L (P<0.01).Statistical differences could be noted, when the percentages of the patient populations with normal , deficient and average 25-( OH) D3 levels were compared between the 2 groups (P<0.01).For the adult group with vitiligo, the percentages of the patient populations with sufficient , normal, insufficient and deficient 25-(OH)D3 levels were 2.3%, 9.3%, 51.2% and 37.2% respectively, averaging(33.2 ±14.5)nmol/L, while the per-centages of the controls were 0, 20.0%, 63.3% and 16.7% respectively, averaging (37.2 ±10.7) nmol/L .Statistical differences could be seen, when the percentages of the patient populations with deficient 25-(OH)D3 level were compared between the 2 groups(P<0.05).Conclusion The pathogenesis of vitiligo was associated with the deficiency of 25-OH D3, which was particularly the case in youngsters .%目的：检测白癜风患者血清25-（ OH） D3和其他羟基化代谢物水平，探讨该指标与白癜风发病的关系。方法采用真空采血管，空腹抽取140例白癜风患者和60例健康体检者静脉血3 ml，1周内用ELISA法进行检测。按血清25-（ OH） D3水平分为足够（74．1～250．0 nmol/L）、正常（47．7～74．0 nmol/L）、不足（25．0～47．6 nmol/L）、缺乏（＜25．0 nmol/L）4种水平，按年龄分为青少年组（5～18岁）、成年组（19～56岁），分别与各年龄对照组进行比较分析。结果青少年白癜风组血清25-（OH）D3处于足够、正常、不足和缺乏水平的分别为0、7．4％、59．3％和33．3％，平均值为（30．6±10．5）nmol/L；青少年对照组分别为10．0％、43．3％、46．7％和0，平均值为（50．1±12．1）nmol/L，2组比较差异均有统计学意义（P＜0．01）。成年白癜风组血清25-（OH）D3处于足够、正常、不足和缺乏水平的分别为2．3％、9.3％、51．2％和37．2％，平均值为（33．2±14．5）nmol/L；成年对照组分别为0、20．0％、63．3％和16．7％，平均值为（37．2±10.7）nmol/L，2组比较差异均有统计学意义（P＜0．05）。结论维生素D严重缺乏与白癜风患者的发病有关，尤其是青少年白癜风患者。
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