A SYNERGISTIC COMPOSITION FOR TREATMENTOF GENERALIZED STABLE/NON-STABLE AND SEGMENTAL VITILIGO, VITILIGO, PATCHES NOT RESPONDING TO PUV-A THERAPY AND FAST SPREADING VITILIGO.

摘要

"A synergistic composition for treatment of generalized stable/non-stable and segmental vitiligo, vitiligo patches not responding to PUV-A therapy and fast spreading vitiligo". Synergistic therapies for the treatment of vitiligo are provided. The major therapies for the treatment of vitiligo a pigmentary disorder characterized by patchy depigmentation of skin are Psoralens plus UV-A, steroids, basic fibroblast growth factor (bFGF) peptide location or surgical procedures. Psoralens plus UV-A is effective in about 50% of cases, steroids or limitedly effective only in fast spreading cases of vitiligo and often reoccurs on stoppage of treatment. Surgical treatment is the last resort for vitiligo therapy, when all other therapies failed. It is limitedly effective. Basic fibroblast growth factor peptide(s) location was developed as a new mode therapy tor the treatment of vitiligo. It is effective in 80% of stable vitiligo and in segmental vitiligo. Here data are provided and demonstrated that combinatorial treatment of vitiligo by local application of bFGF peptide(s) lotion in association with psoralens and UV-A, or steroids or surgical procedures produce synergistic response and that the rate of re-pigmentation increases synergistically and more efficacious results are obtained than with any of them alone. Any combinatorial therapy comprising she local application of bFGF peptide lotion on the vitiligo patch in combination with any o;her therapy for the treatment of vitiligo appears to act synergistically.