乳果糖联合培菲康用于原发性肝癌患者术前肠道准备的安全性与有效性探讨

摘要

目的：探讨乳果糖联合培菲康用于原发性肝癌患者手术前肠道准备的安全性与有效性。方法经患者知情同意，采用数字表法将80例患者随机分为2组，每组40例，分别采用乳果糖联合培菲康（实验组）与聚乙二醇电解质（对照组）口服作为肝癌术前肠道准备药物，比较2组患者肠道准备的耐受性、接受程度、不良反应、肠道清洁程度以及术后肠功能恢复情况。结果2组肠道准备药物口服后肠道清洁程度比较差异无统计学意义（P＞0．05）；2组患者在肠道准备药物的口感和接受程度比较实验组明显优于对照组，差异有统计学意义（P＜0．05）；2组患者肠道准备不良反应除变态反应外，其他项比较差异无统计学意义（P＞0．05）；肠道准备后排便次数及肠功能恢复时间实验组优于对照组，2组比较差异有统计学意义（P＜0．05）。结论 乳果糖联合培菲康作为肠道准备药物是安全可行的，不仅增加患者的舒适感，还可以提高患者的依从性并降低医疗费用。%Objective To study the safety and efficacy of oral lactulose coupled with bifico as pre-surgical bowel preparation in patients with primary liver cancer .Methods With the knowledge and consent of the patients , a total of 80 patients were randomly divided into 2 groups, the experimental group and the control group , each consisting of 40 patients.The experimental group received o-ral lactulose plus bifico and the control group was given oral polyethylene glycol electrolytes as pre -surgical bowel preparation before sur-gery.Then, patients′tolerance, acceptance, adverse reactions, bowel cleansing and post-surgical bowel movement recovery were ob-served and compared between the 2 groups.Results No statistical significance in bowel cleansing could be observed , following imple-mentation of the drugs for the two groups (P>0.05).The texture and acceptance of the drugs for the experimental group were obviously superior to those of the control group, with statistical significance(P<0.05).With the exception of allergic reaction, no statistical difference could be noted in adverse reactions to pre-surgical bowel preparation for both groups (P>0.05).The incidence of other ad-verse reactions for the experimental group was lower than that of the control group , with statistical significance(P<0.05).Following pre-surgical bowel preparation , frequency of defecation and recovery of liver function for the experimental group were superior than those of the control group, also with statistical significance, when comparisons were made between the 2 groups (P<0.05).Conclusion Lactulose coupled with bifico as pre-surgical bowel preparation was safe and feasible , which could not only improve the sense of comfort for the patients, but increased their compliance , and decreased medical cost as well .