加减清营汤治疗乙肝后肝硬化内毒素血症热毒血瘀型的临床研究

摘要

OBJECTIVE To study the effects of modified Qingying Decoction on endotoxin levels of patients with cirrhosis endotoxemia due to hepatitis B.METHODS 58 patients with cirrhosis endotoxemia due to hepatitis B of toxic heat and blood stasis syndrome were randomly divided into treatment group(30 cases) and control group(28 cases).Patients in the control group were treated with hepatoprotective medication therapy,including reduced glutathione injection,Kuhuang injection and diammonium glycyrrhizinate and sodium chloride injection.Based on this,patients in the treatment group were further given Qingying Decoction.The endotoxin levels in the serum of these 58 patients were tested using the dynamic turbidity method,to-gether with serum alanine aminotransferase(ALT),total bilirubin(TBiL) and prothrombin time(PT).RESULTS The treat-ment group was superior to the control group in decreasing clinical symptom integral(P <0.01) and even more superior in re-ducing endotoxin levels(P <0.05).CONCULSION Qingying Decoction has a notable curative effect on cirrhosis endotoxemia due to hepatitis B.%目的：研究加减清营汤对乙肝后肝硬化内毒素血症患者体内的内毒素水平的影响。方法58例确诊的乙肝后肝硬化内毒素血症热毒血瘀型患者随机分为治疗组30例，对照组28例。对照组给予还原型谷胱甘肽、苦黄注射液、甘草酸二胺氯化钠保肝治疗，治疗组在对照组治疗基础上给予加减清营汤治疗。用动态浊度法检测58例乙肝后肝硬化患者血清内毒素水平，并测定血清丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)及凝血酶原时间(PT)等。结果在临床症状积分改善方面治疗组优于对照组(P <0.01)，对内毒素水平的改善，治疗组优于对照组(P <0.05)。结论加减清营汤对乙肝后肝硬化内毒素血症疗效显著。