2－二甲胺基－1－硫代磺酸钠基－3－硫代磺酸基丙烷的合成

摘要

以1－二甲胺基－2,3－二氯丙烷盐酸盐水溶液与硫代硫酸钠为主要原料，合成制得2－二甲胺－1－硫代磺酸钠基－3－硫代磺酸基丙烷。先在0～3 ℃，盐酸盐水溶液中加入定量NaO H制得氯化物，再进行硫代硫酸化反应。用正交设计试验法优选出硫代硫酸化反应最佳工艺条件为：氯化物pH值6.8，反应温度69 ℃，反应时间3.5 h，甲醇用量为每摩尔氯化物600 g ，反应收率从目前工业生产的85.4%提高到95.8%。%2-dimethylamino-l-sodium thiosulfonate-3-thiosulfonic propane has been synthesized by using 1-dimethylamino-2, 3-dichloropropane aqueous hydrochlo ride with solfactol. Technical conditions optimized with orthogonal process were st udied. The product yield was raised from 85.4% to about 95.8%.