process for preparing 2 - (3-pyridyl) - 2 - (tetrahydrothiopyrannecarbothioamide 1 - (1r, 2r), 2tetrahydrothiopyrannecarbothioamide 3-pyridyl) - 2 - (1 - (1r) -2) thus obtained and pharmaceutical compositions which contain them.

摘要

Process for preparing (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides of general formula: IMAGE (R1=alkyl containing 1 to 4 carbon atoms), by the action of an alkyl isothiocyanate on the 1R,2R and 1R,2S sulphoxides of formulae: IMAGE IMAGE employed alone or mixed, the (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides thereby obtained and pharmaceutical compositions containing them. (1R,2R)-2-(3-Pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides are especially useful as antihypertensives.