血清白细胞介素-18与急性冠脉综合征的相关性研究

摘要

目的 探讨不同类型冠心病(CHD)患者中白细胞介素-18水平,观察其与急性冠脉综合征的相关性.方法 71例冠心病患者中急性冠状动脉综合征(ACS)50例,其中急性心肌梗死21例(AMI组),不稳定心绞痛29例(UA组).稳定型心绞痛组(SA组)21例,另选20例为正常对照组采用酶联免疫吸附法检测IL-18水平.结果 ACS组患者血清IL-18水平与ACS组疾病严重程度存在一定相关性.ACS组IL-18水平高于SA组及对照组(P＜0.01),与冠状动脉病变数量呈正相关(r=0.266,P=0.003).结论 在ACS患者中IL-18水平与疾病的严重程度有一定的相关性,可能可作为ACS重要预测指标.%Objective To investigate the relationships between serum level of interleukin (IL-18 ) and acute coronary syndrome (ACS) , and whether IL-18 is a reliable biochemical marker indi eating the severity of ACS. Methods Seventy-one patients including acute coronary syndrome (ACS) ,Amorg,21 cases of acute myocardial infarction(AMI group),29 cases of unstable anginal (UA group). 21 cases of stable angina(SA group) and 20 normal control were studied, Serum concentration of IL-18 was measured by enzyme linked immuno-adsorption assay. Results The concentration of IL-18 in Patients with ACS was correlative with the severity of the diseases,The serum level of IL-18 was obviously higher in the acute coronary syndrome group than that in the stable angina pectoris group and normal control group(P<0. 01) ,and it was positively correlated with the stenosis lesion branches(r=0. 266,P = 0. 003). Conclusion Serum concentrtion of IL-18 In patients with ACS might be a reliable biochemical marker which can objectively indicate the degree of this disease. It may be used as an important prognostic marker for ACS.