目的 探讨患者颈动脉粥样硬化程度、性质与血清胆红素的关系.方法 对存在颈动脉粥样硬化的65例患者进行颈动脉彩色多普勒检查,记录颈动脉粥样硬化斑块的部位、回声强度、颈总动脉分叉处内膜中层厚度及血管内径,并根据颈动脉狭窄程度分为轻、中、重及完全闭塞组.同时检测血清胆红素水平,并进行统计学分析.结果 轻、中、重及完全闭塞组间接胆红素和总胆红素分别为:(11.735±2.275)、(14.860±3.677)μmol·L-1,(9.063±2.174)、(10.744±2.493)μmol·L-1,(7.772±1.823)、(8.417±3.018)μmol·L-1,(4.445±2.060)、(5.055±2.426)μmol·L-1.颈动脉狭窄越严重,间接胆红素、总胆红素值就越小,且间接胆红素、总胆红素与颈动脉狭窄程度呈负相关(r=-0.726、-0.759,P＜0.05).结论 血清胆红素水平降低与颈动脉粥样硬化密切相关,血清胆红素可能在颈动脉粥样硬化的发生发展中起着重要的作用.%Objective To investigate the relationship of carotid atherosclerosis to serum bilirubin and plasm a fibrinogen. Methods Color Doppler examination was performed in 65 patients with carotid atherosclerosis to record plaque position, echo intensity, intima-media thickness of the carotid bifurcation, and vessel diameter. These patients were divided into four groups according to the degree of carotid stenosis: mild, moderate, severe and complete occlusion. In addition, levels of serum bilirubin were detected and results were analyzed statistically. Results The levels of indirect and total bilirubin were, respectively, (11. 735 ± 2. 275) and (14. 860 ± 3. 677)μmol · L-1 in mild occlusion group, (9.063 ± 2.174) and (10.744 ± 2. 493)μmol · L-1 in moderate occlusion group, (7. 772±1. 823) and (8.417 ± 3. 018)μmol · L-1 in severe occlusion group, and (4.445 ± 2. 060) and (5. 055 ± 2. 426)μmol · L-1 in complete occlusion group. The degree of carotid artery stenosis was negatively correlated with the levels of indirect and total bilirubin (r=-0.726 and r=-0.759, respectively; P<0.05). Conclusion Carotid atherosclerosis is associated with the de -creased serum bilirubin concentrations, which may play an important role in the occurrence and development of carotid atherosclerosis.
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