IGF-1R基因在伴或不伴糖尿病的乳腺癌组织中的表达及其相关因素

摘要

Objective:To identify the expression of IGF-1R gene and its relationship with clinical features in breast cancer tissues with or without diabetes and the associated factors. Methods:Immunohistochemistry was em-ployed for detecting IGF-1R gene expression in 68 breast cancer tissues without diabetes and 34 breast cancer tis-sues with diabetes,and its adjacent breast tissues.Results:Significant difference of IGF -1R gene expression was found between the breast cancer tissues and adjacent breast tissues (P＜0.05).There were significant relationship between expression of IGF-1R gene and tissues of size and TNM stage.What＇s more,there was significant relation-ship in breast cancer without diabetes between expression of IGF-1R gene and lymphatic metastasis status.Conclu-sion:IGF-1R gene expression is up-regulated in human breast cancer tissues and related to size and TNM stage, but not to patient age.There is significant relationship between expression of IGF-1R gene and lymphatic metastasis status in breast cancer without diabetes.%目的:检测IGF-1R基因在伴或不伴糖尿病的乳腺癌组织中的表达,并探讨其与乳腺癌临床病理因素的关系.方法:利用免疫组织化学SP法检测68例不伴糖尿病的乳腺癌组织及相应的癌旁组织中IGF-1R蛋白的表达情况,与34例伴糖尿病的乳腺癌组织及相应的癌旁组织中IGF-1R蛋白的表达情况,并分析其与病人年龄、TNM分期、肿瘤大小及淋巴结转移等临床病理特征之间的相关性.结果:伴或不伴糖尿病的乳 腺癌组织中IGF-1R蛋白的表达水平明显高于其相应的癌旁组织(P＜0.05).伴或不伴糖尿病的乳腺癌组织中IGF-1R的表达与肿瘤的大小及TNM分期有关(P＜0.05),而与患者年龄无关.不伴糖尿病的乳腺癌组织中IGF-1R的表达与患者淋巴结转移状态有关(P＜0.05),而伴糖尿病的乳腺癌组织中IGF-1R的表达与患者淋巴结转移状态无关(P＞0.05).结论:IGF-1R基因在乳腺癌组织中的表达显著上调;IGF-1R基因的表达与肿瘤大小、TNM分期有关,而与年龄无关.不伴糖尿病的乳腺癌组织中IGF-1R的表达与患者淋巴结转移状态有关,而伴糖尿病的乳腺癌组织中IGF-1R的表达与患者淋巴结转移状态无关.