环境介导的耐药性促成微小残留病变的研究进展

摘要

Environment - mediated drug resistance is a form of de novo drug resistance that protects tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease can then develop complex and permanent acquired resistance in response to the pressure of therapy. Recent evidence indicates that environment - mediated drug resistance arises from an adaptive, reciprocal signalling dialogue between tumour cells and the surrounding microenvironment, that new therapeutic strategies targeting this interaction should be applied during initial treatment to prevent the emergence of acquired resistance.%环境介导的耐药性(environment-mediated drug resistance,EMDR)是一种新形成的耐药性形式,可以在不同治疗方案的最初阶段保护肿瘤细胞.尚存的残余病灶能够发生复杂而持久的获得性耐药,以适应治疗的选择压力.最近的研究表明,EMDR从肿瘤细胞相互之间和周围微环境信号的传导中出现.因此,针对这种新的治疗策略应该在初始治疗中应用,以防止获得性耐药.