mcr-1基因介导黏菌素耐药性研究进展

摘要

黏菌素是人类及动物防御多重耐药革兰阴性菌感染的最后一道防线.2015年底报道的质粒介导的黏菌素耐药基因 mcr-1在革兰阴性菌水平传播,并在世界各地广泛存在,加剧了人们对耐药性的担忧.论文介绍了 mcr-1介导黏菌素耐药性情况、在细菌和宿主的传播、mcr-1阳性菌在全球的传播、耐药机制、mcr-1遗传背景、与其他耐药基因的共存情况以及 mcr-1以外的质粒介导的黏菌素耐药机制,为黏菌素的合理使用提供理论依据.%Colistin is the last resort for the control of multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated colistin resistance gene mcr-1 was reported via horizontal transfer at the end of 2015.It exists worldwide,and catalyses the concern over the resistance.Here,we comprehensively reviewed mcr-1-mediated colistin resistance,dissemination of mcr-1 in bacteria and hosts,distribution of mcr-1-positive bacteria,resistance mechanism,genetic background,co-existance with other resistance genes,and plasmid-mediated colistin resistance mechanism independent of mcr-1,which may provide the theory evidence for the reasonable use of colistin.