目的:探讨窖蛋白-1 ( Caveolin-1 ) 在乳腺癌间质中的表达及其与乳腺癌发生、发展及转移的关系.方法:运用免疫组织化学 SP法研究Caveolin-1在正常乳腺癌间质和正常乳腺间质中的表达.结果:80例乳腺癌组织中间质Caveolin-1的表达阳性率分别为55%,而在36例正常乳腺组织中间质Caveolin-1的表达阳性率为75%,两者比较有显著差异(P=0.042);间质Caveolin-1的表达阳性率在乳腺癌高、中分化组明显高于低分化组,转移阳性组明显高于转移阴性组,其差异均有统计学意义( P=0.025 );复发组间质Caveolin-1的表达阳性率也明显低于未复发组,其差异有统计学意义 ( P=0.012 ).K-M生存曲线显示间质Caveolin-1的表达阴性患者的无瘤生存率也明显低于间质Caveolin-1的表达阳性患者( P=0.008 ).多因素COX逐步回归分析结果显示间质Caveolin-1是无瘤生存率( P= 0.031)的独立因素.结论:间质Caveolin-1可能在乳腺癌的发生、发展及转移过程中起着关键性作用.%Objective : To detect the stromal expression of Caveolin - 1 in breast cancer, and evaluate the association between clinicopathological parameters and breast carcinogenesis. Methods : By immunohistochemical SP method, the expression of stromal Caveolin - 1 in the tissues of 80 cases of breast cancer patients and 36 cases of normal ones were evaluated, and its relationship with clinical and pathological features was analyzed. Results : The positive rate of stromal Caveolin - 1 in normal breast tissue was 55％ , which was significantly higher than 35％ of the breast cancer ( P = 0. 042 ). The positive rate of stromal Caveolin - 1 expression in the high differentiated and moderately differentiated groups was significantly higher than the poorly differentiated group, and metastasis negative group was significantly higher than the positive ones( P = 0. 025 ); the positive rate of stromal Caveolin - 1 expression was significantly higher in the recurrence group than the group without recurrence ( P = 0. 012 ). K - M survival curve showed the survival rate was significantly lower in the negative expression of the stromal Caveolin - 1 patients compared to the positive ones ( P = 0. 008 ). Multivariate COX proportional hazards model analysis also showed that the expression rate of the stromal Caveolin - 1 was an independent predictor of disease - free survival ( P = 0. 031 ). Conclusion: Loss of stromal Caveolin - 1 may play an important role in the development and metastasis of breast cancer.
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