多种肿瘤标志物蛋白芯片检测系统(C-12)对老年肺癌转移诊断的临床价值研究

摘要

Objective;Using multiple tumor marker protein chip detecting system (C-12) to test the level of multiple tumor markers in old lung cancer patients, and investigating the clinical significance of C-12 in diagnosing and evaluating metastasis of old patients with lung cancer. Methods: Using C -12 to detect the level of 12 serum multiple tumor markers and calculate the positive rale. We selected 111 cases (age^50 years) including controls (n = 31), lung benign disease group (n = 23), lung cancer without metastasis (n = 24) and lung cancer with metastasis (n =33). Results: Compared with controls, lung cancer without metastasis group had a higher level of serum CA19 -9,C,CA242,AFP,CA125 and CA15 -3 (P<0.05); While lung cancer with metastasis group had a significant increase in the level of serum CA19-9, NSE, CEA, CA242, Ferritin, |3-HCG, AFP,CAI25,HGH and CA15-3 (P <0.05). And lung cancer with metastasis group had both higher level and positive rate of CA19-9, CEA, CA242, Ferritin,CA15 -3 than lung cancer without metastasis group. Conclusion: Combining detection of CA19 -9,CEA, CA242,Ferritin,CA15 -3 can be diagnostic parameters for evaluating metastasis of old patients with lung cancer.%目的:利用多种肿瘤标志物蛋白芯片检测系统(C-12)检测老年肺癌患者各项肿瘤标志物的水平,并探讨C-12对老年肺癌患者是否发生转移的临床监测价值.方法:利用多种肿瘤标志物蛋白芯片检测系统检测年龄50岁以上的正常对照组(n=31)、肺部良性疾病组(n=23)、肺癌未转移组(n=24)以及肺癌转移组(n=33)血清12种肿瘤标志物水平并计算阳性率.结果:肺癌未转移组血清CA19-9、CEA、CA.242、AFP、CA125和CA15-3的水平明显高于正常对照组(P＜0.05),而肺癌转移组血清CA19-9、NSE、CEA、CA242、Fe蛋白、β-HCG、AFP、CA125、HGH和CA15-3这10项肿瘤标志物水平均显著高于正常对照组(P＜0.05).肺癌转移组与肺癌未转移组相比,CA19-9、CEA、CA242、Fe蛋白、CA15-3这5项肿瘤标志物水平和阳性率均明显升高(P＜0.05).结论:联合检测血清CA19-9、CEA、CA242、Fe蛋白、CA15-3的水平可以作为老年肺癌患者发生转移的辅助诊断指标.