目的:探讨缺血修饰白蛋白预测对多柔比星导致心功能下降的价值.方法:选取2007年-2010年在我科用多柔比星治疗的52例患者,根据IMA值,将52例患者分为IMA增高组(IMA+)及未增高组(IMA-),分析2组在化疗结束后0、3、6、9及12月心脏彩超LVEF值变化情况.结果:52例患者心功能LVEF整体出现下降趋势.2组间0、3、6、9及12个月LVEF值随着时间的变化LVEF变化并且两组存在差异,有统计学意义(P＜0.01).对同一时间测量的LVEF进行比较发现在化疗后第9、12个月时两组的LVEF存在差别,有统计学意义(P＜0.01),IMA+组心功能LVEF值下降程度要高于IMA-组.结论:在多柔比星化疗后导致患者心功能下降方面,曾有IMA的增高者心功能下降程度高于IMA未增高者.%Objective: To study the value of ischemia modified albumin to predic doxorubicin resulted in decreased cardiac function. Methods: According to IMA, 52 patients were divided into IMA increased group and without increased group to analyse the LVEF value at the end of chemotherapy after 0,3,6,9 and 12 months. Results; For 52 patients cardiac function decreased LVEF at 0,3,6,9 and 12 months of changed with time( P<0.01). Conclusion; Doxorubicin resulted in patients with decreased cardiac function, in IMA increased group the declined function of the heart is higher than that of IMA non increased group.
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