节律性化疗在血液肿瘤治疗应用的研究进展

摘要

近几年发现某些化疗药物在低剂量、长时间接触中可选择性抑制血管内皮细胞的功能，且不受肿瘤细胞耐药状态的影响，与传统的最大耐受量化疗不同，主要是剂量低，间歇期短，能持续应用。本文对节律性化疗在血液病患者中的应用、作用机制、优势及其与其他治疗方法结合等方面的现状和前景进行综述。%In recent years,we found that certain chemotherapy drugs in low dose and prolonged exposure could selec-tively inhibit vascular endothelial cell function,and not subject to the state of drug - resistant tumor cells,differ from conventional chemotherapy of the maximum tolerated dose mainly in low dose,short intermittent duration,and continu-ance to apply. In this essay,we reviewed the status quo and prospects of rhythmic chemotherapy in the application, mechanism,advantages and their combination with other treatment methods in patients of hematonosis.