三阴性乳腺癌细胞免疫状态和 Th1/Th2细胞因子的变化

摘要

目的：探讨三阴性乳腺癌的细胞免疫状态和 Th1/ Th2细胞因子的变化。方法：比较46例三阴性乳腺癌患者和60例非三阴性乳腺癌患者的临床资料，分析三阴性乳腺癌组、非三阴性乳腺癌组和对照组的细胞免疫状态及 Th1/ Th2细胞因子的变化。结果：三阴性乳腺癌和非三阴性乳腺癌两组相比，在发病年龄、月经状况、临床分期、组织学分级情况没有统计学差异（P >0.05）；在淋巴结转移和内脏转移方面有统计学差异（P<0.05）。乳腺癌患者 CD3、CD4、CD19 T 细胞亚群无改变，CD8和 CD69水平有变化，但后两者在三阴性乳腺癌和非三阴性乳腺癌组中没有统计学差异（P >0.05）。乳腺癌患者 IL -2分泌减少，IL -6、IL -10分泌高，存在 Th2漂移。结论：三阴性乳腺癌转移风险高，预后差。乳腺癌存在 Th1/ Th2失衡，但三阴性乳腺癌和非三阴性乳腺癌相比，并没有明显的 Th2优势，说明三阴性乳腺癌发病机制具有更为复杂的生物学因素。%Objective:To investigate cellular immune state and the change of Th1 / Th2 cytokines. Methods:Clini-copathological data were compared between the 46 cases of triple negative breast cancer(TNBC)and 60 cases of non- triple negative breast cancer(non - TNBC). Cellular immune state and the change of Th1 / Th2 cytokines were ana-lyzed with 40 cases of control group,TNBC patients and non - TNBC patients. Results:There had not significant differences in disease onset,menstrual status,clinical stages,tumor histologic grade(P > 0. 05),but had significant differences in lymph note positivity and metastatic status between TNBC and non - TNBC patients(P < 0. 05). The expression of CD3,CD4,CD19 had no significant change compared with control group,the variety of CD8 and CD69 had no differences between the TNBC patients and non - TNBC(P > 0. 05). IL - 6,IL - 10 expression levels in breast cancer was higher than that in healthy control group(P < 0. 05),but IL - 2 expression level was lower,the balance be-tween Th1 and Th2 shifts to the direction of Th2. Conclusion:TNBC has high risk of metastasis and poor prognosis. The unbalance of Th1 / Th2 was obvious in breast cancer,but there is not significant Th2 advance in TNBC. It indi-cates more complex biological factors in TNBC pathogenesis.