中国人群ALDH2(E487K)基因多态性与肝细胞肝癌易感相关性研究的Meta分析

摘要

Objective:To study the relationship between aldehyde dehydrogenase 2(ALDH2)with the susceptibili-ty of hepatocellular carcinoma(HCC)in Chinese population. Methods:Published literatures from PubMed,Embase and CNKI databases were retrieved.Pooled odds ratio(OR)with 95% confidence interval(CI)was calculated using fixed- or random-effects model according to the heterogeneity.Results:Seven studies including 1 053 HCC cases and 1 172 controls were included in this meta-analysis.The association between ALDH2(E487K)polymorphism and HCC susceptibility was found under allele model(OR=0.86,95% CI=0.75 ~0.99).Conclusion:Our analysis showed that ALDH2(E487K)polymorphism was marginally associated with HCC susceptibility.%目的:通过Meta分析系统评价中国人群中乙醛脱氢酶2(ALDH2)基因多态性和肝细胞肝癌(HCC)易感性的相关性.方法:检索PubMed、EMBASE和CNKI等中、英文数据库中发表的关于中国人群ALDH2基因多态性和HCC易感性的关系.对文献进行质量评价、筛选和提取相关病例对照研究资料,应用R软件(R-3.2.0)进行Meta分析,计算合并OR和95%CI.结果:共纳入7篇文献进行研究,累计病例组1053例,对照组1172例.分析结果显示在等位基因模型下,ALDH2(E487K)基因多态性与HCC易感性具有相关性(OR=0.86,95%CI=0.75~0.99).结论:本次Meta分析结果提示,在中国人群中,ALDH2(E487K)基因多态性与HCC易感性具有一定相关性.