Objective:To explore the clinicopathological characteristics,differential diagnosis,treatment and prog-nosis in primary extraskeletal chondroma of the greater omentum. Methods:The clinical data of a 33-year-old woman was analyzed. Hematoxylin-eosin staining and immunohistochemistry were performed and the results were an-alyzed. In addition,we reviewed the domestic and international literature. Results:Ultrasound and computed tomo-graphy showed a mass in the abdomen of patient. Grossly,the tumor was lobulated,well-circumscribed,hard and gray. Around the tumor,there was a part of greater omentum. Histopathologically,the tumor was composed of mature hyaline cartilage,and arranged like lobular. The cells were not atypical. Immunohistochemically,S-100 was positive and Ki67 index was below 1％ . The patient was doing very well with no complaints or metastasis after 2 years. All of the features were in accordance with the primary extraskeletal chondroma of the greater omentum. Resection was con-sidered as the recommended therapy. Conclusion:The primary extraskeletal chondroma of the greater omentum is very rare,and the etiology is unknown. The therapy should be chosed is surgical resection.%目的:探讨大网膜原发性骨外软骨瘤的临床病理特征、鉴别诊断、治疗及预后.方法:分析一例33岁女性患者的临床资料,对病理标本进行常规HE染色和免疫组化染色,对染色结果进行分析判读,并检索国内外文献进行复习.结果:超声及CT均提示患者腹腔有包块;大体标本检查肿瘤组织部分呈分叶状,界清、质硬、灰白,周边见部分网膜组织;组织病理检查肿瘤由成熟透明软骨构成,呈小叶状排列,细胞无异型性;免疫组化检测肿瘤组织S-100阳性,Ki67阳性指数<1％;随访患者3年无复发或转移,各项结果共同支持大网膜原发性骨外软骨瘤的诊断,临床治疗方法首选完整切除.结论:大网膜原发性软骨瘤极其罕见,其发病机制尚不明确,治疗以手术完整切除为主.
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