来那度胺治疗弥漫大B细胞淋巴瘤的进展

摘要

Lenalidomide as an immunomodulator has been widely used in multiple myeloma. It not only can directly induce the apoptosis of tumor cells,but also plays an important role in immune regulation via inflammatory cytokines, NK cells and regulatory cells. In addition,a number of basic and clinical researches confirmed that lenalidomide can also play a very important role in diffuse large B cell lymphoma (DLBCL)therapy,no matter for the newly diagnosed or relapsed/ refractory DLBCL patients. Lenalidomide monotherapy or combination of R - CHOP or other regimens have achieved good results. This article is to review the advances of lenalidomide in the treatment of DLBCL.%来那度胺作为免疫调节药物已被广泛应用于多发性骨髓瘤的治疗,其不仅能直接诱导肿瘤细胞凋亡,还通过炎症因子、NK细胞、调节T细胞等发挥重要的免疫调节作用.此外,多项基础及临床研究均证实来那度胺在弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)治疗中也可起到非常重要的作用,无论对初诊还是复发/难治DLBCL患者,来那度胺单药或联合R-CHOP等方案均取得较好的治疗效果.本文旨在综述来那度胺在治疗DLBCL的进展.