乌司他丁对脓毒症患者降钙素原水平的影响及临床意义

摘要

Objective To explore the curative effect and clinical significance of ulinastatin on procalcitonin (PCT) in patients with sepsis. Methods A total of 60 patients with sepsis,who were received from March to December of 2013,were ran-domly divided into treatment group(n=31) and control group(n=29). The treatment group was injected with ulinastatin with the dosage of 10 000 U/(kg·d),while the control group received normal saline with the same dose of the treatment group,24 h con-tinuously intravenous macro-pump for 7 d. Peripheral blood was withdrawn in both groups 1 d before administration and 7 d after administration to measure the PCT level,and the 28 d hospital fatality rate was observed. Results The PCT level 7 d after admin-istration in the treatment group was lower than that in the control group in the same period ,and the 28 d hospital fatality rate in the treatment group was lower than that in the control group, the differences between the two groups all had statistical significance(P<0.05). Conclusion Ulinastatin can reduce PCT level in patients with sepsis,inhibit inflammation response and decrease 28 d hospital fatality rate.%目的：探讨乌司他丁对脓毒症患者降钙素原（PCT）水平的影响及临床意义。方法将2013年3~12月收治的60例脓毒症患者随机分为治疗组（31例）和对照组（29例），治疗组给予注射用乌司他丁1万U/（kg·d），对照组给予同等剂量生理盐水，均24h持续静脉微量泵入，连续7d。两组患者均于用药前1d和用药7d后清晨抽取外周血检测PCT水平，并观察28 d住院病死率。结果治疗组用药7 d后PCT水平低于同期对照组，28 d住院病死率低于对照组，差异均有统计学意义（P<0.05）。结论乌司他丁能降低脓毒症患者体内PCT水平，拮抗炎性反应，降低28 d住院病死率。