乌司他丁对ICU脓毒症患者降钙素原、C反应蛋白水平及预后的影响

摘要

OBJECTIVE:To probe into the effects of ulinastatin on PCT,CRP levels and prognosis in ICU sepsis patients.METHODS:70 ICU sepsis patients admitted into Sihui People's Hospital from Aug.2014 to Aug.2016 wereaccording to admission order grouping,single number as the observation group,double number as the control group,with 35 cases in each.The control group was given conventional treatment,while the observation group additionally received ulinastatin based on the control group.Two groups were treated with 7 d.The clinical efficacy and prognosis of two groups were observed.The PCT,CRP levels and differences of numeration of leukocyte and oxygenation index of two groups were compared.RESULTS:The total effective rate of observation group was significantly higher than that of control group,with statistically significant difference(P<0.05).After treatment,the PCT,CPR levels were lower than those of before treatment,and the observation group was lower than the control group;the numeration of leukocyte of observation group was significantly lower than that of control group,yet the oxygenation index was higher than the control group,with statistically significant difference(P<0.05).The check-in time of ICU in observation group was shorter than that of control group,and themortality rate in observation group was significantly lower than that of control group,with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of ulinastatin on PCT,CRP levels and prognosis in ICU sepsis patients is remarkable,which can reduce patients' PCT,CRP levels and improve the prognosis.%目的:探讨乌司他丁对重症加强护理病房(intensive care unit,ICU)脓毒症患者降钙素原(PCT)、C反应蛋白(CRP)水平及预后的影响.方法:选取2014年8月-2016年8月四会市人民医院收治的ICU脓毒症患者70例作为研究对象,按照入院顺序分组,单号为观察组,双号为对照组,每组35例.对照组患者给予常规治疗,观察组患者在对照组基础上加用乌司他丁治疗,两组患者均连续治疗7 d.观察两组患者的临床疗效及预后情况,比较两组患者治疗前后PCT、CRP水平及白细胞计数、氧合指数的差异.结果:观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05).治疗后,两组患者PCT、CRP水平明显低于治疗前,且观察组明显低于对照组;观察组患者白细胞计数明显低于对照组、氧合指数明显高于对照组,差异均有统计学意义(P<0.05).观察组患者ICU入住时间明显短于对照组、病死率明显低于对照组,差异均有统计学意义(P<0.05).结论:乌司他丁用于ICU脓毒症患者的疗效显著,可降低患者PCT、CRP水平,改善预后情况.