测定血清胃蛋白酶原在幽门螺杆菌感染的各种胃疾病中的应用价值

摘要

目的 探讨血清胃蛋白酶原测定与幽门螺杆菌感染的各种胃部病变的关系和临床诊断价值.方法 选取幽门螺杆菌抗体IgG阳性的病例168例.其中浅表性胃炎45例,萎缩性胃炎32例,消化性溃疡53例(胃溃疡28例,十二指肠溃疡25例),胃癌38例;正常对照组54例.应用乳胶增强免疫比浊法测定血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)以及计算PGⅠ/PGⅡ的比值.采用ELISA方法检测幽门螺杆菌抗体IgG.结果 胃癌组血清PGⅠ,PGⅠ/PGⅡ的比值明显低于正常对照组(P<0.01),萎缩性胃炎组血清PGⅠ低于正常对照组(P<0.01),消化性溃疡组血清PGⅠ,PGⅠ/PGⅡ明显高于正常对照组(P<0.01).浅表性胃炎患者与对照组比较,血清PGⅠ无明显差异.结论 血清胃蛋白酶原Ⅰ,PGⅠ/PGⅡ的比值可作为诊断幽门螺杆菌感染的各种胃疾病的参考指标.%Objective To eaplore the relationship and value of serum pepsinogen levels and gastric lesious infacted by helici-bactor pylori(HP). Methods Selected anti-HP positive 168 cases. 45 cases of chronic superficial gastric. 32 cases of chronic atrophic gastric,28 cases with gastric ulcer and 25 cases with erosine gastritis. 38 cases with gastric cancer and 54 cases with normal control. Pepsinogen levels was detected with turbidivetry. Helicibactor pylori antibody was deteced with ELISA method. Results The PG I levels and the ratio of PG I /PG II were negative correlated with gastric cancer and decreased significantly than the normal control group(P<0.01) . The level of PG I was negative correlated with atrophic gastritis and decreased than the normal control group(P<0.01). The level of PG I was direct correlated with peptic ulcer and increased significantly( P<0.01). There was no statistical difference of the PG I level between chronic superficial gastritis caese and healthy peoples. Conclusion The levels of PG I and the ratio of PG I /PGII were reference indication of diagnosis of various gastropathy infected by helicibactor pylori.