内源性一氧化碳与疾病的关系

摘要

机体组织和细胞中的一氧化碳(Carbon monoxide,CO)可因吸入外界环境中的CO或内源性产生.内源性CO在体内的产生,碳氧血红蛋白(COHb)的形成,呼出CO水平受生理和病理状态的影响.内源性CO可作为机体氧化和炎症状态的标志物.某些疾病时内源性CO生成量增加,于是干扰CO正常信号通路,增加机体毒性危害.%Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or endogenously.Endogenous CO production, carboxyhemoglobin (COHb) formation, and exhaled CO levels are influenced by physiological and pathologial factors.Endogenous CO can be used as a biomarker for oxidative and inflammatory state.Endogenous CO can contribute to increased body burden of CO, which may both disrupt normal CO signaling cascades and increase the risk of CO toxicity.