预注阿曲库铵对不同剂量顺式阿曲库铵时效的影响

摘要

Objective To observe the affection of pre-injection of atracurium in small dosage on the age of ED95 of cisatracurium of different dosages. Methods 80 cases of ASAI II for surgery were randomly divided into 4 groups, 20 cases in each:Group A with 3 ED95 of cisatracurium(0.15mg/kg), Group B with 4 ED95 of cisatracurium(0.2mg/kg), Group C with pre-injection of atracurium(0.1mg/kg)plus 3ED95 of cisatracurium and Group D with pre-injection of atracurium(0.1mg/kg)plus 4ED95 of cisatracurium;an observation was made to the onset time, the effective duration and the time for recovery after operation in each group and the tracheal intubation con-dition and side-effects were estimated. Results There existed no obvious difference in the onset time of atracurium between Group A and Group B(P<0.05)while the onset time of Group C and of Group D was shorter than those of Group A and Group B(P<0.05), the onset time of Group D was the shortest(P<0.05);the effective duration of Group B and of Group D was longer than those of Group A and Group D(P<0.05), the effective duration of Group D was the longest(P<0.05);the time for recovery after operation in Group B and in Group D was obviously longer than those in Group A and Group C(P<0.05)and it took the longest in Group D(P<0.05);tra-cheal intubation condition in Group A was unsatisfactory, and 1 case suffered from slight cough in Group B while the tracheal intuba-tion condition in Group C and in Group D was good. Conclusions Pre-injection of atracurium in small dosage(0.1mg/kg)plus 4ED95 of cisatracurium can make the onset time shorter, clinical effective duration longer, recovery after operation quicker, tracheal intubation condition more satisfactory and less side effects, which is worthy of wide application in clinic.%　　目的观察预注小剂量阿曲库铵对不同ED95顺式阿曲库铵时效的影响.方法将80例ASAI-II级手术患者随机分为四组(n=20)：A组3ED95(0.15 mg/kg)顺式阿曲库铵、B组4ED95(0.2 mg/kg)顺式阿曲库铵、C组预注射0.1 mg/kg阿曲库铵,复合3ED95顺式阿曲库铵、D组预注射0.1 mg/kg阿曲库铵,复合4ED95顺式阿曲库铵.观察各组顺式阿曲库铵起效时间、临床有效作用时间、术毕恢复时间；评估气管插管条件及不良反应.结果 B组与A组相比,B组顺式阿曲库铵起效时间无明显差异(P>0.05),而C、D两组起效时间较A、B组明显缩短(P<0.05),D组更短(P<0.05)；有效作用时间B、D组较A、C组延长(P<0.05),D组最长(P<0.05)；术毕恢复时间B、D组较A、C组明显延长(P<0.05),D组恢复时间最长(P<0.05).A组行气管插管不满意,B组有1例轻微呛咳；C、D组气管插管条件满意.结论预注射小剂量(0.1 mg/kg)阿曲库铵复合4 ED95顺式阿曲库铵,肌松起效时间短,临床有效作用时间长,术毕恢复快,气管插管条件满意,不良反应少,适合临床推广.