目的：阐明ER、PR、p53及c-met基因表达与乳腺癌患者临床分期、淋巴结转移及肿瘤大小等因素进行临床相关性分析。方法：采用免疫组织化学染色方法测定p53、c-met基因以及雌激素受体、孕激素受体，将实验结果整理后应用SPSS13软件进行统计分析。结果：p53、c-met基因表达与乳腺癌患者腋窝淋巴结转移及肿瘤临床分期呈正相关。与病理组织类型以及ER、PR的表达之间差异无显著性意义。结论：联合检测 ER、PR、p53及c-met基因对乳腺癌的淋巴结转移、预后判断及指导临床化疗具有十分重要的意义。%To study the expression of ER ,PR ,p53 and c-met gene in breast cancer and analyze it's the cor-relation with tumor clinical classification ,lympho node metastasis and neoplasm diameter of breast cancer patients . Methods :The c-met gene ,p53 gene ,estrogen receptor(ER) and pregnant receptor(PR) were detected by immunohisto-chemistry method .All the experimental data were analyzed by software SPSS10 .0 .Results:The expressions of c-met gene and p53 gene have a positive correlation with the axilla lympho nodes metastasis and tumor clinical classification . The expression has no crrelation with the pathohistological type and the estrogen receptor and pregnant receptor ex-pression rate .Conclusion:Combined detection of ER ,PR ,p53 and c-met gene gene is of great importance in the predic-ting the lympho nodes metastasis ,prognosis judgement and clinical comprehensive treatment performation .
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