目的：建立连云港地区心脏机械瓣膜置换术后早期华法林抗凝模型。方法：收集我院2010年9月-2013年9月心脏机械瓣膜置换手术采用华法林抗凝的患者，随机分为两组，起始剂量3．75mg组（A组）和起始剂量5mg组（B组），进行对比研究。比较两组抗凝起始剂量、维持剂量、抗凝强度、术后到达抗凝达标时间、抗凝稳定时间、术后抗凝并发症等。结果：A、B组抗凝模型均取得良好的抗凝结果；相比而言，B组模型比A组模型更有利于抗凝达标和稳定，抗凝并发症发生率比较无明显差别。结论：建立心脏机械瓣膜置换术后早期华法林抗凝模型，降低抗凝并发症发生率，从而降低医疗费用，改善患者长期生活质量。%Established early in Lianyungang warfarin model mechanical heart valve replacement surgery . Methods:Collected in our hospital in September 2010 to September 2013 mechanical heart valve replacement surgery pa-tients using warfarin were randomly divided into two groups ,the starting dose of 3 .75mg group (A) and the starting dose of 5mg group (group B) ,comparative study .Starting dose anticoagulation were compared ,the maintenance dose , anticoagulation intensity ,postoperative anticoagulation reach compliance time ,stable anticoagulation ,postoperative anti-coagulation complications .Results:A ,B group anticoagulant models have achieved good results anticoagulation;con-trast ,group B than in group A model anticoagulant standard model and more conducive to stable anticoagulation was no significant difference in the incidence of complications .Conclusion:A ,B group anticoagulant models have achieved good results anticoagulation;contrast ,group B than in group A model anticoagulant standard model and more conducive to stable anticoagulation was no significant difference in the incidence of complications .
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